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New York, US, August 30, 2019 Creative Biolabs, an undisputed global leader focusing on therapeutic antibodies, offers various therapeutic antibodies including but limited to human antibodies, mouse antibodies, complement-dependent cytotoxicity (CDC)-enhanced antibodies for the research of a wide variety of diseases.Monoclonal antibodies have played essential roles in biochemistry, molecular biology, and medical research for years, which are most well-known for the significant use as therapeutic agents to treat plenty of diseases, such as immune disorders, cancers, and infections.
Based on an advanced antibody discovery platform at Creative Biolabs, the fully human antibodies are developed in compliance with the hypothesis that mAbs derived from human sequences would prove to be less immunogenic than mouse, chimeric or humanized mAbs. The improved safety, higher efficacy and commercial value presented by human antibodies make them a promising and rapidly growing role among a wide range of targeted therapeutic agents.
Generally, mouse antibodies account for most of early therapeutic antibodies since mouse is the predominant animal host for monoclonal antibody production. Creative Biolabs provides several methods to produce high-quality mouse antibodies, for instance, hybridoma technique, by fusing immortal mouse myeloma cells and splenic B cells from immunized animals. Meanwhile, the recombinant technology is also available to meet the rapid growth in demand for antibody production and serious animal welfare concerns.
As for CDC-enhanced antibody, experienced scientists from Creative Biolabs have developed a Crea-Tag™ protein that can be co-expressed as a fusion protein with any antibody to activate complement-mediated lysis by displacing the complement factor H (CFH) on tumor cells. Scientists clone Crea-Tag into pIRES-neo and pIRES-DHFR to produce N- and C-termini, light and heavy chain fusions, and concentrate antibodies using YM-100 membrane. LysTag-modified antibodies can be produced in Chinese hamster ovary (CHO) cells and HiTrap Protein G-Sepharose is used for HPLC antibody purification.
“With years of efforts in the antibody field, our team has accumulated sufficient knowledge and skills that help better solve different problems in collaboration with our customers. Our Crea-Tag™ Based CDC Enhance Services provide fully equipped molecular biology laboratory and mammalian cell culture, and standardized animal facilities and comprehensive animal models. FACS and in vivo molecular imaging are prepared for a detailed result.” Introduced by the senior scientist in Creative Biolabs.
More information can be reached at https://www.creativebiolabs.net.
About Creative Biolabs
Creative Biolabs was founded by scientists who are dedicated to the treatment of a wide variety of diseases, including immune disorders, cancers, infections and more. Over the last 10 years, Creative Biolabs has become a leader of recombinant antibody (rAb) discovery and manufacturing, providing high quality service to customers in academia and industry fields all over the world. The cutting-edge hybridoma development and phage display platforms allow the production of the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price.
Contact Info:
Name: Candy Swift
Email: Send Email
Organization: Creative Biolabs
Address: 45-1 Ramsey Road, Shirley, NY 11967, USA
Website: https://www.creativebiolabs.net
Release ID: 88913841
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