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Targeting the young drug research and development technology proteolysis targeting chimerics (PROTAC) that clears specific oncogenic proteins in cells by utilizing the cell’s own protein destruction mechanism, Creative Biolabs provides a list of services to expedite relevant research progress on a global scale, including PROTAC molecule discovery, PROTAC in vitro evaluation, and PROTAC in vivo animal test.The molecule discovery package involves the entire pipeline of PROTAC molecule development, ranging from ligand design for target protein, ligand screening, linker design and optimization, structural modification to compound synthesis to ensure that the outcomes possess high standard degradation selectivity. It’s worth noting that all the provisions can be in package or separately to cater to customers with varied research targets.
Ligand design of target protein, the preliminary and indispensable procedure to determine PROTAC’s specificity and affinity, accepts more than cytosolic, nuclear and trans-membrane targets, but also transcription factors, non-enzymatic proteins, scaffold proteins, kinases, receptors or bromodomains can find counterpart proposals at Creative Biolabs.
As for the customers that only require to determine the efficiency of PROTACs, it’s wise to provide their interested E3 ligases to Creative Biolabs for ligand screening, which is supported by skillful technical staff based upon the advanced platform.
Various linkers are provided together with the optimization solution to assist with connecting the small molecule for E3 ubiquitin ligase recognition and a ligand for protein recognition, of which the linkers can be adjusted in length and location so as to reach optimal effect.
A further step to make perfect the PROTAC is structural modification that aims at enhancing pharmacological properties and other drug-like properties, and meanwhile resolves the limitations brought by poor molecule stability, biodistribution, and cellular permeability in vivo. The crucial step is accomplished in various strategies at Creative Biolabs to help develop ideal PROTACs with the best properties as drug candidates.
Last but not the least, peptide and compound synthesis services stand as the complement of the PROTAC discovery procedure, through which peptide and compound can get synthesized for delivery. The procedures are operated with a variety of platforms, formats, modifications and purity levels optional, supported by the trendy FMOC solid-phase technology for synthesis, and HPLC for purification.
“Our services and products can help you develop the best PROTACs for new therapeutics,” said the technical lead of Creative Biolabs. Since the establishment in 2004, dozens of successful cases and a lot of regular customers prove the actual strength of this conscientious CRO. More details can be reached at https://www.creative-biolabs.com/protac/.
About the company
Creative Biolabs is a professional in the field of antibody development & engineering with a group of dedicated scientists working hard for decades, whose faith lies in accelerating the world’s step toward precision medicine. With high-end technologies and well-experienced scientists, the PROTAC solutions can accelerate any associated research worldwide.
Contact Info:
Name: Candy Swift
Email: Send Email
Organization: Creative Biolabs
Address: 45-1 Ramsey Road
Phone: 1-631-619-7922
Website: https://www.creative-biolabs.com/protac/
Release ID: 88945859
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