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Antibody-drug conjugates (ADCs) are composed of antibodies and cytotoxic drugs, conjugated by chemical linkers. They combine the abilities of mAbs and cytotoxic drugs, improving the control of drug pharmacokinetics and allowing specific drug delivery to target cells. A number of ADCs have been researched and entered clinical trials in recent years. And the successful FDA approval of brentuximab vedotin (Adcetris®, SGN-35) and ado-trastuzumab emtansine (Kadcyla®, T-DM1) further suggests that ADCs are promising therapeutic agents for oncotherapy.Based on its ADC platform, Creative Biolabs provides comprehensive custom services to develop numerous ADC products for every stage of development from antibody expression to cGMP manufacturing.
Antibody Modification and Conjugation
Creative Biolabs now provides various strategies for antibody modification and conjugation in antibody drug conjugate (ADC) development. According to the different reactive sites, the conjugation strategies can be classified into non-specific conjugation through native residues, site-specific conjugation through genetically engineered sites and UV cross-linking. Non-specific conjugation technologies are based on the principle of utilizing reactive side chains of naturally occurring amino acids, such as lysine and cysteine. Site-specific conjugation can increase the site specificity of ADC conjugation by altering amino acid sequences to introduce reactive handles, which includes thio-engineered antibodies (THIOMAB) and enzymatic modified antibodies. UV cross-linking is also a site-specific conjugation but does not require genetic engineering or pre-activated scaffolds. It is suitable to the payloads featuring a UV reactive indole-3-butyric acid (IBA) moiety.
“According to the characteristics of antibodies and special requirements from clients, we can select the most appropriate conjugation strategy for the ADCs of their interest”, said Monika, scientific officer of Creative Biolabs
About Creative Biolabs
Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical products and services that cover the full scope of biotechnology needs of early antibody drug discovery and development, such as antibody conjugation service and conjugation antibody.
Contact Info:
Name: Candy Swift
Email: Send Email
Organization: Creative Biolabs
Address: 45-1 Ramsey Road
Phone: 5166698109
Website: http://www.creativebiolabs.net/
Release ID: 128898
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